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Research

This is a compiled list of resources that explain about dermaroller research.

  1. Henry et al. demonstrated that microneedles of 150m/m length resulted in a 10,000 increase in absorption of calcein by the skin after the microneedles were removed. Henry S, McAllister DV, Allen MG, Prausnitz MR. Microfabricated microneedles: a novel approach to transdermal drug delivery. J Pharm Sci. 1998 Aug;87(8):922-5
  2. Kaushik et al (28) carried out a small trial to determine if microneedles are perceived as painless by human subjects. Microneedle arrays of 150�m length, were inserted into the skin of 12 subjects and compared to pressing a flat surface against the skin (negative control) and inserting a 26-gauge hypodermic needle into the skin surface (positive control). Subjects were unable to distinguish between the painless sensation of the flat surface and that caused by microneedles. Kaushik S, Hord AH, Denson DD, McAllister DV, Smitra S, Allen MG, Prausnitz MR. Lack of pain associated with microfabricatedmicroneedles. Anesth Analg. 2001 Feb;92(2):502-4.
  3. Fernandes D. demonstrated that microneedling can induce up to a 1,000% increase in collagen after a single treatment. Fernandes D. Minimally invasive percutaneous collagen induction. Oral Maxillofac Surg Clin North Am 2006;17:51-63.
  4. Camirand, A. & Doucet, J. Demonstrated in case studies on a large number of patients that skin needling improves achromic, hypertrophic and unsightly scars in a simple safe and consistently effective way. Camirand, A. & Doucet, J. Needle Dermabrasion. Aesth. Plast. Surg. 21: 48-51, 1997.
  5. Derma roller better than IPL for Scar treatments Kim SE, Lee JH, Kwon HB, Ahn BJ, Lee AY.Greater collagen deposition with the microneedle therapy system than with intense pulsed light.Department of Dermatology, Graduate School of Medicine Medical Science Research Center, Dongguk University, Seoul, Gyeonggi-do, South Korea Reborn Dermatology Clinic, Seoul, South Korea.Dermatol Surg. 2011 Mar;37(3):336-41. doi: 10.1111/j.1524-4725.2011.01882.x. Epub 2011 Feb 22.
  6. Aust MC, Knobloch K, Reimers K, Redeker J, Ipaktchi R, Altintas MA, Gohritz A, Schwaiger N, Vogt PM.Percutaneous collagen induction therapy: an alternative treatment for burn scars.Department for Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Carl-Neubergstr. 1, 30625 Hannover, Germany. aust_matthias@gmx.deBurns. 2010 Sep;36(6):836-43. Epub 2010 Jan 13.
  7. Percutaneous Collagen Induction Therapy: An Alternative Treatment for Scars, Wrinkles, and Skin Laxity Aust, Matthias C. M.D.; Fernandes, Des M.D.; Kolokythas, Perikles M.D.; Kaplan, Hilton M. M.D.; Vogt, Peter M. M.D; Plastic & Reconstructive Surgery:April 2008 - Volume 121 - Issue 4 - pp 1421-1429 doi: 10.1097/01.prs.0000304612.72899.02. Showed an increase in collagen and elastin deposits at 6 months and 40 percent thickening of stato spinosum at 1 year after1-4 treatments for wrinkles lax skin, scarring stretch marks.
  8. Aust MC, Vogt PM, Knobloch K Percutaneous collagen induction therapy as a therapeutic option for striae distensae Plast Reconstr Surg. 2010 Oct;126(4):219e-220e
  9. Percutaneous Collagen Induction Therapy for Hand Rejuvenation, Matthias Aust, Karsten Knobloch; Andreas Gohritz, Peter M Vogt, Desmond Fernande; Plastic, Hand, and Reconstructive Surgery; Hannover Medical School; Hannover, Germany (Aust, Knobloch, Gohritz, Vogt) Department of Plastic and Reconstructive Surgery; Grooteschuur Hospital; Renaissance Body Science Institute; Cape Town, South Africa (Fernandes).
  10. Percutaneous collagen induction-Regeneration in place of cicatrisation? M C Aust, K Reimers, H M Kaplan, F Stahl, C Repenning, T Scheper, S Jahn, N Schwaiger, R Ipaktchi, J Redeker, M A Altintas, P M Vogt; Department for Plastic, Hand and Reconstructive Surgery, Medizinische Hochschule Hannover, Hannover, Germany. Journal of plastic, reconstructive & aesthetic surgery : JPRAS. 04/2010; DOI: 10.1016/j.bjps.2010.03.038
  11. Percutaneous collagen induction: An alternative to laser resurfacing Des FernandesDes Fernandes, MD, Cape Town, South Africa, is a plastic surgeon. Aesthetic surgery journal / the American Society for Aesthetic Plastic surgery. 06/2002; 22(3):307-9. DOI: 10.1067/maj.2002.126195
  12. Combating photoaging with percutaneous collagen induction; Desmond Fernandes, Massimo Signorini; The Renaissance Surgical Clinic and Department of Plastic Reconstructive Surgery, University of Cape Town,Cape Town 8001, South Africa. Clinics in dermatology. 26(2):192-9. DOI: 10.1016/j.clindermatol.2007.09.006
  13. Minimally invasive percutaneous collagen induction; Desmond FernandesThe Shirnel Clinic and Department of Plastic Reconstructive Surgery, University of Cape TownOral and maxillofacial surgery clinics of North America. 03/2005; 17(1):51-63. DOI: 10.1016/j.coms.2004.09.004
  14. Percutaneous Collagen Induction: Minimally Invasive Skin Rejuvenation without Risk of Hyperpigmentation-Fact or Fiction?Aust, Mathias C. M.D.; Reimers, Kerstin Ph.D.; Repenning, Claudia Ph.D.; Stahl, Frank Ph.D.; Jahn,Sabrina B.A.; Guggenheim, Merlin M.D.; Schwaiger, Nina M.D.; Gohritz, Andreas M.D.; Vogt, Peter M.
  15. M.D.J Drug Target. 2010 Jan;18(1):15-20. Hair Regrowth Trial Effect of applying modes of the polymer microneedle-roller on the permeation of L-ascorbic acid in rats; You SK, Noh YW, Park HH, Han M, Lee SS, Shin SC, Cho CW; College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon